#Lack of sex drive ed free#

They were divided into Group (A):34 patients treated with metformin 500mg tid (metformin hydrochloride tablet USA, corona CA 92880 USA), Group (B): 30 patients treated with sulfonylurea (Glibenclamide) 5mg/day (Daonil tablet, AVENTIS PHARMA LIMITED, VERNA, Goa-403722) and Group (C): 27 healthy normal non-diabetic men subjects that are regarded as control, all controlled subjects were recruited from healthy medical staff at hospital. Р”Р„ total number of 64 patients with well diagnosed type 2 DM (the range of disease duration was 7 years) associated with erectile dysfunction on either metformin or glibenclamide therapy were recruited from the Iraqi Endocrinology Center involved in this study. The study procedures were done in respect to the Declaration of Helsinki. This study was permitted and approved by the Ethics Committee, Al-Mustansiriyia Medical College under ethical clearance number DD208 PT.

This case control study was carried out in the Department of Clinical Pharmacology and Therapeutic, College of Medicine, Al-Mustansiriyia University in collaboration with the Iraqi Endocrinology Center from January to February 2016 in Baghdad-Iraq. Thus, the aim of the present study was to evaluate the erectile dysfunction and sex drive in relation to testosterone serum levels in type 2 DM and also scrutinize the potential role of diabetic pharmacotherapy upon these changes. Р”Р‡urthermore, metformin therapy leads to significant reduction in testosterone serum levels in diabetic and non-diabetic patients while, sulfonylurea (glimepiride) restore testosterone serum levels in type 2 DM patients. Metformin is an insulin sensitizing agent that increases insulin sensitivity and reduced androgen serum levels through inhibition of ovarian gluconeogenesis in women with polycystic ovary syndrome.

#Lack of sex drive ed free#

Many longitudinal studies demonstrated that men with low testosterone levels are at higher risk for development of type 2 DM due to induction of insulin resistance, since free testosterone levels are inversely corelated with insulin resistance. Men with type 2 DM are found to have hypogonadism and high Body Mass Index (BMI), since there is an inverse corelation between free or total testosterone with high BMI in addition Sex Hormone Binding Globulin (SHBG) is low in patient with type 2 DM with and without obesity. Indeed, patients with diabetic-induced erectile dysfunction with low testosterone respond weakly to sildenafil and respond better to the testosterone replacement therapy that also causes improvement in insulin sensitivity, glucose and lipid homeostasis. Furthermore, other factors like increasing age, impaired penile blood flow and peripheral neuropathy with low testosterone are often responsible for type 2 DM-induced erectile dysfunction. Moreover, low testosterone serum levels are more linked with type 2 DM coupled with obesity causing sexual dysfunction, physical fatigue and mood changes.

Recent studies demonstrated that men with type 2 DM have low testosterone levels that cause low sex drive and erectile dysfunction. Likewise, low testosterone is associated with the pathogenesis of type 2 DM. Recently, higher endogenous testosterone secretion has been correlated with beneficial effect on cardiometabolic profile through induction of High Density Lipoproteins (HDL) and reduction in serum levels of cholesterol and triglyceride, whereas exogenous testosterone leads to harmful effects causing dyslipidemia and various hepatic dysfunctions. The role of insulin is essential for glucose homeostasis via induction of peripheral tissue glucose uptake, inhibiting hepatic glucose output and regulating lipid metabolism in cooperation with other hormones like catecholamine, cortisol, growth hormone and glucagon. Type 2 DM is an endocrine disorder accounting for 90% of diabetes cases, characterized by hyperglycaemia, polyuria, polydepsia, polyphagia and weight loss due to impaired insulin action and/or secretion. Sex drive and desire are regulated by sex hormones and affected by psychological factors and metabolic diseases like DM. Also, decrease libido and orgasmic dysfunction are commonly associated with erectile dysfunction in patients with type 2 Diabetes Mellitus (DM). Erectile dysfunction is a well-recognized complication in diabetes mellitus and it is common in older men.